|
KMID : 1161420180210050489
|
|
Journal of Medicinal Food
2018 Volume.21 No. 5 p.489 ~ p.495
|
|
|
Neuroprotective Effects of the Methanol Extract of Kimchi, a Korean Fermented Vegetable Food, Mediated Via Suppression of Endoplasmic Reticulum Stress and Caspase Cascade Pathways in High-Cholesterol Diet-Fed Mice
|
|
Kim Se-Rim
Woo Min-Ji
Kim Mi-Jeong
Noh Jeong-Sook
Song Yeong-Ok
|
|
|
Abstract
|
|
|
|
Endoplasmic reticulum (ER) stress-related unfolded peptide accumulation is closely associated with the development of neurodegenerative diseases known as protein misfolding disorders. The antioxidative properties of kimchi, a traditional Korean fermented vegetable dish, have been well established. In this study, the neuroprotective effects of the kimchi methanol extract (KME) were examined in high-cholesterol diet (HCD)-fed mice. The animals were fed a HCD, with oral administration of either KME (KME group, 200?mg·kg bw?1·day?1, n?=?10) or distilled water (Control group, n?=?10) for 8 weeks. Compared with the levels in the control group, the reactive oxygen species, peroxynitrite, and lipid peroxidation levels in the brain were significantly decreased in the KME group (P?
|
|
|
KEYWORD
|
|
|
apoptosis, brain, endoplasmic reticulum stress, inflammation, oxidative stress
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|